Stomach Cramps: Causes, Remedies, and What to Take for Relief

What Do We Mean by “Stomach Cramps”?

When people refer to “stomach cramps” or “stomach pain”, they most often mean discomfort in the upper and central abdomen, the region below the ribcage and above the navel. However, from a medical perspective, this area is far from straightforward.

The abdomen can be divided into nine anatomical regions, each overlying specific organs that may be responsible for pain felt in that area:

• The upper six regions (epigastrium, right and left hypochondria, right and left flanks, and umbilical region) are associated not only with the stomach itself, but also with the duodenum (the first section of the small intestine), the liver, the gallbladder, the pancreas, the spleen, and portions of the intestine.
• A further layer of complexity arises from referred pain. This is discomfort perceived in the upper abdomen that actually originates from organs in the chest, such as the heart, lungs, pleura, and esophagus. Classic examples include the epigastric discomfort that can accompany a heart attack, or the upper abdominal pain of lower lobe pneumonia.

This is why “stomach pain” is inherently a vague clinical descriptor. A physician must systematically evaluate the symptom by examining its precise location, character, timing, and associated features. This thorough assessment is essential to arrive at an accurate diagnosis.

Medical evaluation becomes particularly important when stomach cramps are accompanied by:

• Fever
• Nausea and/or vomiting
• Changes in the color or quantity of urine or stool
• Jaundice (yellowing of the skin or eyes)
• A tense, rigid abdomen
• Breathing difficulties
• Pregnancy

In any of these situations, prompt medical assessment is essential rather than optional.

According to population studies, approximately 25% of the general population experiences abdominal pain at some point. This makes it one of the most prevalent medical complaints worldwide and one of the most common reasons for both primary care visits and emergency department presentations.

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Types of Abdominal Pain

Before examining causes, it is useful to understand how abdominal pain is classified. The character of the pain itself provides important diagnostic information.

Patients describe upper abdominal discomfort in a wide variety of ways: “cramps”, “stabbing pains”, “burning”, “pressure”, “heaviness”, “nausea”, “indigestion”, or simply “feeling unwell”. While these terms are used loosely and often interchangeably in everyday language, they reflect genuine qualitative differences that a physician will seek to characterize systematically.

Pain is assessed across several dimensions:

Intensity and Quality

• Mild, dull discomfort: a background sense of unease or pressure, often associated with functional conditions.
• Sharp or stabbing pain typically suggests a more acute process like mucosal inflammation or muscular spasm.
• Burning: a symptom characteristic of acid-related conditions, such as gastritis, peptic ulcer, or GERD.
• Cramping: intermittent, wave-like contractions, typical of smooth muscle spasm in the gastrointestinal tract.
• Colicky pain is a particularly intense form of cramping. It builds to a peak, eases, and then recurs. This type of pain is characteristic of conditions like gallstones, kidney stones, or bowel obstruction.

Location and Radiation

• Generalized and vague: often felt diffusely across the abdomen, this type of pain may be functional or caused by gas.
• Localized: confined to a specific quadrant, which helps narrow the differential diagnosis.
• Migrating refers to moving from one area to another over time. For example, appendicitis classically begins as periumbilical pain that shifts to the right lower quadrant.
• Referred to distant sites, such as the back (as in pancreatitis), the shoulder (as in gallbladder disease or diaphragmatic irritation), or the groin (as in renal colic).

Timing and Pattern

• Continuous: unremitting pain that does not come and go, suggesting ongoing organic pathology.
• Intermittent: it comes and goes in waves. This pattern is typical of smooth muscle spasm, such as in the bowel, gallbladder, or ureter.
• Nocturnal: pain that wakes the patient from sleep. This is an important feature suggesting organic rather than functional disease. Peptic ulcer, for example, classically causes nocturnal pain.
• Relationship to meals:
  • Pain that appears or worsens after eating may indicate conditions such as a gastric ulcer, gallbladder disease, or gastritis.
  • Pain that improves with eating or occurs when fasting may indicate a duodenal ulcer. In this case, food temporarily neutralizes stomach acid.
  • Pain unrelated to meals: functional disorders or non-gastrointestinal causes.
• Relationship to bowel movements: Pain that worsens with defecation or is relieved by it suggests a large bowel origin. This pattern is consistent with IBS or colitis.
• Relationship to posture or physical activity: Musculoskeletal causes of abdominal pain typically vary depending on position or movement.

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Causes of Stomach Cramps

The causes of upper abdominal cramps and pain can be organized into two fundamental categories:

Organic Causes

Organic causes are those where structural anatomical damage can be identified through imaging or laboratory investigations. Examples include findings on ultrasound, endoscopy, CT scan, or MRI. These are conditions in which something is physically wrong with the architecture of the affected organ.

Functional Causes

Functional causes are those where organs appear anatomically normal during examination. There are no ulcers, masses, or structural abnormalities, yet the organs still do not function properly. The nervous supply to the organ, or its capacity to contract in a coordinated and appropriate manner, is disrupted. Functional gastrointestinal disorders are significantly harder to diagnose than organic ones, precisely because conventional investigations return normal results, and the diagnosis rests on clinical pattern recognition using validated criteria (such as the Rome IV criteria for IBS and functional dyspepsia).

The Major Causes of Upper Abdominal Pain

Indigestion, Food Poisoning, and Gastroenteritis

Indigestion (dyspepsia) refers to upper abdominal discomfort related to eating. Common symptoms include bloating, early satiety, nausea, and epigastric pain or burning. It may be functional (no identifiable organic cause) or secondary to conditions such as peptic ulcer or H. pylori infection.

Food poisoning and gastroenteritis cause cramps, nausea, vomiting, and diarrhea through direct mucosal irritation by ingested pathogens or their toxins. These are typically self-limiting but can occasionally cause serious dehydration requiring medical attention.

Food Allergies and Intolerances

Food allergies or intolerances are common and frequently underdiagnosed causes of recurrent upper and lower abdominal cramps:

• Lactose intolerance: When the body lacks sufficient lactase, undigested lactose passes into the colon. There, bacteria ferment it, causing gas, bloating, cramping, and diarrhea.
• Celiac disease (gluten intolerance): An autoimmune condition in which gluten ingestion triggers an immune response that damages the small intestinal lining. Symptoms include abdominal cramps, bloating, diarrhea, and malabsorption.

Gastroesophageal Reflux Disease (GERD)

GERD occurs when stomach acid flows back into the esophagus, causing heartburn and upper abdominal discomfort. Typical symptoms include a burning sensation behind the sternum, an acid taste in the mouth, and regurgitation. In severe cases, patients may also experience chest pain that can be mistaken for cardiac disease.

Hiatal Hernia

An hiatal hernia occurs when part of the stomach pushes upward through the diaphragm into the chest cavity. It frequently coexists with and worsens GERD, and may cause upper abdominal or lower chest discomfort, particularly after meals.

Helicobacter Pylori Infection

H. pylori is a bacterium that colonizes the stomach lining and is responsible for the majority of peptic ulcers worldwide. Infection may be asymptomatic or may cause epigastric pain, bloating, or nausea. If ulceration develops, however, the pain typically becomes more severe and characteristic. It is detected through breath tests, stool antigen testing, or endoscopic biopsy, and is treated with a combination of antibiotics and acid suppressants.

Gastric and Duodenal Ulcers

Peptic ulcers are open sores on the inner lining of the stomach (gastric ulcer) or the duodenum (duodenal ulcer). They represent a genuinely important and relatively common cause of upper abdominal pain:

• Gastric ulcer: Pain typically begins or worsens after eating, as food stimulates acid secretion.
• Duodenal ulcer: Pain classically improves after eating (food temporarily buffers acid) but recurs 2–3 hours later when the stomach empties. It is also particularly associated with nocturnal pain, a clinically important feature that helps distinguish it from functional dyspepsia.

Both types may be accompanied by nausea, vomiting, and loss of appetite. Complications include bleeding, which may present as blood in vomit or black tarry stools, and perforation. Both conditions are medical emergencies.

Gallstones and Cholecystitis

Gallstones are crystallized deposits that form in the gallbladder. When a stone obstructs the cystic duct, it triggers biliary colic, a characteristically severe, cramping pain in the right upper quadrant. This pain often radiates to the right shoulder or back and typically occurs after fatty meals. Inflammation of the gallbladder (cholecystitis) causes more persistent pain with fever and tenderness on palpation.

Pancreatitis

Acute pancreatitis, inflammation of the pancreas, causes severe, sharp pain in the upper central abdomen. This pain classically radiates to the back in a “belt-like” pattern (the so-called “bar pain”). It is frequently accompanied by nausea, vomiting, and fever. Acute pancreatitis ranges from mild and self-limiting to life-threatening and requires medical assessment.

Constipation, Diarrhea, and Bloating

Constipation, diarrhea, and bloating, whether occurring independently or together, are major contributors to abdominal cramping. Gas produced by intestinal bacteria can accumulate under pressure within the colon, creating significant pain that is sometimes felt in the upper abdomen or even confused with chest pain. This is particularly true of gas trapped at the splenic flexure of the colon (the left upper quadrant area), which can mimic left-sided chest pain.

Inflammatory Bowel Disease, Colitis, and Diverticulitis

Crohn’s disease, colitis, and diverticulitis all involve inflammation of specific portions of the bowel. Symptoms typically include abdominal cramping and pain, altered bowel habits, fever, and nausea. These are significant medical conditions requiring proper diagnosis, ongoing management, and in some cases specialist gastroenterological care.

Irritable Bowel Syndrome (IBS)

IBS is a chronic functional gastrointestinal disorder defined by the Rome IV criteria. To meet these criteria, a patient must experience recurrent abdominal pain at least one day per week, along with at least two of the following conditions: pain related to defecation, pain linked to a change in stool frequency, or pain connected to a change in stool form. Bloating, diarrhea, constipation, or alternating patterns are common companions. Symptoms are characteristically triggered or worsened by stress and eating. IBS affects an estimated 10–15% of the population globally and is the most commonly diagnosed gastrointestinal condition in clinical practice.

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Symptoms and How Pain Evolves

One of the clinically important features of gastrointestinal pain is its recognizable temporal evolution. Understanding this sequence helps in diagnosis and in distinguishing serious from self-limiting causes.

Stage 1: True Visceral Pain

In the early phase of an abdominal process, pain is characteristically vague and poorly localized. The patient struggles to point to a specific location and instead describes a general sense of “pressure”, “heaviness”, or “unease” in the upper or central abdomen, typically below the sternum or just beneath it.

This vagueness occurs because the visceral organs (stomach, intestines, gallbladder, etc.) are supplied by the autonomic nervous system, which provides less precise spatial information than the somatic nervous system that supplies skin and muscles. The brain therefore cannot accurately localize the source.

At this stage, neurovegetative symptoms are typically prominent:

• Nausea
• Vomiting
• Palpitations or bradycardia
• Diarrhea or constipation
• Changes in urine output

Emotional manifestations, such as anxiety, a sense of dread, or restlessness, are also frequently reported at this stage. These reactions are a normal neurological response to visceral pain.

Stage 2: Referred Pain

If the underlying process continues, the pain becomes referred. This means it is perceived at skin, subcutaneous tissue, or muscle sites that are distant from the actual origin. This occurs because the dermatomes (skin segments) corresponding to those anatomical areas receive the same spinal nerve input as the affected organ, causing the brain to “mislocalize” the pain.

At this stage the pain becomes more specific, easier to characterize, and less dominated by neurovegetative features. Classic examples include:

• Gallbladder pain referred to the right shoulder or right upper back
• Pancreatic pain referred to the mid-back
• Cardiac pain referred to the left arm, jaw, or epigastrium

Stage 3: Referred Pain with Hyperalgesia

In the final stage, especially when the pathological process is prolonged or intensifies, the affected area develops hyperalgesia: a heightened sensitivity to stimulation. External pressure applied to the area produces pain disproportionate to the stimulus, and this tenderness may persist even after the underlying organ process has resolved.

The classic example is the Giordano sign in renal colic: sharp percussion over the costovertebral angle (flank) produces pain well beyond the area of stimulation, and this tenderness can persist after the passage of the kidney stone.

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Diagnosis

Given the breadth of possible causes, arriving at a precise diagnosis for stomach cramps requires a systematic, multi-step approach.

Clinical Assessment

The physician begins with a detailed medical history and physical examination. Key questions address:

• The precise location, character, and intensity of pain
• Its relationship to meals, bowel movements, posture, and specific foods
• The presence of accompanying symptoms (nausea, vomiting, fever, weight loss, changes in stool)
• Medication use, particularly NSAIDs, antibiotics, and acid suppressants, can have significant effects
• Relevant past medical history, family history, and lifestyle factors

Physical examination includes abdominal palpation (assessing tenderness, rigidity, organomegaly, and masses), auscultation of bowel sounds, and assessment of general condition.

Laboratory Investigations

Depending on clinical suspicion, blood, urine, and stool tests may be requested:

• Blood tests: Full blood count, inflammatory markers (CRP, ESR), liver function tests, amylase and lipase (pancreatic enzymes), kidney function, thyroid function, and specific antibodies (e.g., for celiac disease)
• Stool tests: Fecal occult blood, stool culture, H. pylori antigen, fecal calprotectin (marker of intestinal inflammation)
• Urine analysis: To exclude urinary tract causes of referred abdominal pain
• Breath tests: For H. pylori and lactose intolerance

Instrumental Investigations

• Abdominal ultrasound: First-line imaging for gallbladder, liver, kidney, and pancreatic assessment
• Upper endoscopy (gastroscopy): Direct visualization of the esophagus, stomach, and duodenum; allows biopsy for H. pylori, celiac disease, or malignancy
• X-ray: Useful for detecting perforation (free air under the diaphragm) or obstruction
• MRI and CT scan: High-resolution cross-sectional imaging for complex or uncertain cases

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Remedies: What to Do

The treatment of stomach cramps should ideally target the underlying cause rather than merely suppressing the symptom. Effective management depends entirely on what is driving the pain.

Possible therapeutic approaches include:

• Dietary and nutritional interventions, the cornerstone for many gastric and functional conditions, play a critical role in treatment.
• Pharmacological treatment, which may target the pain directly or address its underlying cause.
• Surgical or procedural interventions are indicated for structural problems, such as gallstones, severe hiatal hernia, or complicated peptic ulcer.
• Psychological and lifestyle interventions, particularly relevant for functional conditions driven by stress and anxiety.

Diet and Nutrition

Dietary management is highly specific to the underlying cause. General principles and condition-specific guidance include:

For Gastroesophageal Reflux, Gastritis, and Peptic Ulcers

The priority is to minimize gastric mucosal irritation by reducing exposure to acid-stimulating and irritating substances. Evidence-based dietary recommendations include:

• Eliminate or strictly limit: alcohol, coffee, fried foods, fatty meals, spicy foods, tomato-based products, citrus juices, and carbonated beverages
• Stop smoking: nicotine impairs the protective gastric mucus layer and increases acid secretion
• Eat smaller, more frequent meals to avoid gastric overdistension and minimize post-meal acid surge
• Avoid lying down within 2–3 hours after eating to reduce nocturnal reflux episodes
• Raise the head of the bed slightly if nocturnal reflux is a problem

For a detailed dietary guide, see: Dietary management of reflux and gastritis.

For Viral Gastroenteritis

During and immediately after gastroenteritis, the priority is fluid and electrolyte replacement combined with easily digestible foods:

• Prioritize oral rehydration: water, clear broths, oral rehydration solutions.
• Follow the BRAT approach initially: Bananas, Rice (plain, boiled), Applesauce, and Toast. These are bland foods that are easy to digest and low in irritating fiber.
• Avoid: dairy products, fatty foods, spicy dishes, raw vegetables, alcohol, and caffeine until recovery is complete.

For a detailed dietary guide, see: Diet during diarrhea, nausea, and vomiting.

For Food Intolerances and Allergies

The treatment is elimination of the offending food from the diet:

• Lactose intolerance: eliminate or significantly reduce dairy products; lactase enzyme supplements can allow occasional dairy consumption; lactose-free dairy alternatives are widely available
• Celiac disease: strict, lifelong gluten-free diet is the only effective treatment. All products containing wheat, barley, rye, and often oats must be eliminated
• For other food intolerances: a structured elimination and reintroduction protocol, ideally guided by a registered dietitian, to identify triggers systematically

General Dietary Principles for Abdominal Health

Regardless of the specific underlying cause, the following general principles support digestive health:

• Eat slowly and chew thoroughly. Rushing meals and inadequate chewing increase the amount of air swallowed and the digestive burden on the stomach.
• Maintain a regular eating schedule. The gastrointestinal tract functions best when fed at consistent times.
• Prioritize whole, minimally processed foods. Fruits, vegetables, legumes, whole grains, and lean proteins provide the fiber, vitamins, and minerals that support gut microbiome health and normal intestinal motility.
• Avoid ultra-processed foods, which are high in additives, preservatives, unhealthy fats, and refined carbohydrates that can disrupt gut function.
• Manage stress actively, The gut-brain axis means psychological stress directly affects gastric function, acid secretion, and intestinal motility.

Medications

Medications for stomach cramps fall into two broad categories: those that directly relieve pain, and those that address the underlying cause of the pain (which may secondarily reduce it). Both categories are important.

Medications Addressing the Underlying Cause

Proton pump inhibitors (PPIs) and antacids

• These are the primary pharmacological treatments for acid-related conditions, such as GERD, gastritis, and peptic ulcers. PPIs (such as omeprazole, esomeprazole, pantoprazole) reduce gastric acid secretion by up to 90%, allowing mucosal healing and symptom relief. They do not have direct analgesic properties but are highly effective at eliminating the pain caused by acid-related mucosal damage. Antacids (e.g., calcium carbonate, magnesium hydroxide) neutralize existing acid and provide rapid but short-lived relief.

H. pylori eradication therapy

• When H. pylori infection is confirmed, a standard eradication regimen is prescribed. This usually involves a PPI combined with two antibiotics, most commonly amoxicillin and clarithromycin or metronidazole, for 7 to 14 days. Successful eradication resolves the infection, allows ulcer healing, and prevents recurrence.

Antibiotics and anti-infectives

• For bacterial gastroenteritis or specific infections, targeted antibiotic therapy may be required depending on the causative organism.

Prokinetic agents

• Medications such as domperidone or metoclopramide enhance gastric emptying and coordinated intestinal motility. They are useful when delayed gastric emptying (gastroparesis) contributes to nausea, bloating, and post-meal discomfort.

Medications That Directly Relieve Pain

NSAIDs (non-steroidal anti-inflammatory drugs)

• Agents such as ibuprofen and ketoprofen provide analgesic and anti-inflammatory effects and are useful for cramping pain of muscular or inflammatory origin. Critical caveat: NSAIDs can worsen or even cause gastritis and peptic ulceration through inhibition of prostaglandin synthesis, which is essential for maintaining the gastric mucosal protective layer. In patients with acid-related conditions, their use should be minimized or avoided, and when necessary, they should be combined with a PPI.

Paracetamol (acetaminophen)

• A safer analgesic choice for patients with gastric pathology, as it does not affect prostaglandin synthesis in the gastrointestinal tract. Effective for mild-to-moderate pain when used at appropriate doses.

Antispasmodics (spasmolytic agents)

• These medications specifically target smooth muscle spasm, the mechanism behind many forms of abdominal cramping.

• Hyoscine butylbromide: An anticholinergic that relaxes gastrointestinal smooth muscle. Widely used for biliary colic, intestinal spasm, and IBS-related cramping. Available as tablets or injection.

• Trospium (Spasmex®): Another anticholinergic antispasmodic used for smooth muscle disorders.

• Mebeverine: A more selective intestinal smooth muscle relaxant with fewer systemic anticholinergic effects.

• Enteric-coated peppermint oil: A natural antispasmodic that acts through calcium channel antagonism; supported by meta-analytic evidence for IBS.

Centrally Acting Analgesics and Adjuvants: For chronic pain conditions, especially those involving functional gastrointestinal disorders, a specialist may prescribe the following.

• Antidepressants (low-dose): Tricyclic antidepressants (e.g., amitriptyline) and SSRIs act on the gut-brain axis to reduce visceral hypersensitivity and pain perception. Used off-label at doses below those prescribed for depression.
• Antiepileptics (e.g., gabapentin, pregabalin): Act on central pain processing pathways and may be considered for refractory functional pain.
• Opioids: Minor (e.g., tramadol) or major opioids may be prescribed in specific situations of severe, refractory pain. However, they are used with great caution in gastrointestinal disorders because they reduce intestinal motility. This can worsen constipation and bloating and may occasionally lead to opioid-induced bowel dysfunction.

Important note regarding NSAIDs in acid-related conditions: While NSAIDs may provide temporary pain relief in conditions such as gastritis or peptic ulcer, they simultaneously worsen the underlying mucosal damage. This creates a problematic cycle: the pain is temporarily masked, but the condition is advancing. Patients with known gastric pathology should discuss analgesic choices carefully with their doctor.

Natural Remedies

Natural remedies for stomach cramps work best as complementary approaches. These are supportive measures that can reduce discomfort while the underlying cause is being addressed. They may also help with mild, self-limiting episodes of cramping.

Heat Therapy

One of the most consistently effective natural approaches for abdominal cramping is the application of localized heat. A warm water bottle, heat pad, or warm damp cloth applied to the upper abdomen provides:

• Muscular relaxation: Heat directly reduces smooth muscle tone, which in turn decreases the intensity of spasmodic contractions. This is the same mechanism that helps heat relieve menstrual cramps or back pain.
• Vasodilation: Increased local blood flow supports tissue oxygenation and metabolic waste clearance.
• Nervous system modulation: Warmth activates thermoreceptors and may inhibit pain signals through gate control mechanisms.

Heat therapy is safe, inexpensive, and effective for many types of cramping pain. It is particularly useful while waiting for pharmacological treatment to take effect.

Chamomile Tea

Chamomile (Matricaria chamomilla) has well-documented antispasmodic and mild anti-inflammatory properties. Its active constituents, such as apigenin and bisabolol, have demonstrated smooth muscle relaxant effects in preclinical and some clinical studies. A warm cup of chamomile tea can provide genuine relief from mild upper abdominal cramping and gastric discomfort.

Ginger

Ginger (Zingiber officinale) has substantial evidence supporting its efficacy as an antiemetic and digestive aid. Gingerols and shogaols, the active compounds in ginger, have prokinetic (motility-enhancing) and anti-inflammatory effects on the gastrointestinal tract. Ginger tea or fresh ginger in warm water can be helpful for nausea and mild abdominal discomfort accompanying cramps.

Peppermint

Peppermint (Mentha piperita), especially when taken as an enteric-coated capsule, has shown antispasmodic effects in some clinical trials for IBS. These effects are comparable to those of pharmaceutical antispasmodics. As a tea, its effects are milder but may still provide symptomatic relief for mild cramping and bloating.

Fennel

Fennel seeds or fennel tea have traditional use for relieving gas, bloating, and intestinal spasm. Anethole, the primary active compound, has smooth muscle relaxant properties and may help reduce the severity of gas-related abdominal cramping.

Rest and Posture

For cramping associated with stress or functional disorders, lying in a comfortable position can help. Try curling on one side in the fetal position, or lying on your back with your knees gently bent. These positions reduce abdominal muscular tension and may provide partial relief while the cramp resolves.

Stress Reduction

For cramps with a clear functional or stress-related component, active stress management is not a peripheral concern but a core therapeutic approach. Techniques such as deep breathing, progressive muscle relaxation, mindfulness meditation, yoga, and, where appropriate, psychological support can directly reduce the frequency and intensity of stress-driven gastrointestinal symptoms.

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Bibliography and Sources

• Johns Hopkins Medicine. 5 reasons your stomach may hurt. https://www.hopkinsmedicine.org/health/wellness-and-prevention/5-reasons-your-stomach-may-hurt
• SIMI Handbook: Terapia Medica. 2017. Edra S.p.A., Vignate (MI).
• Drossman, D.A. (2016). Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology, 150(6), 1262–1279.
• Lacy, B.E., Mearin, F., Chang, L., et al. (2016). Bowel disorders. Gastroenterology, 150(6), 1393–1407.
• Ford, A.C., Moayyedi, P., Lacy, B.E., et al. (2014). American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. American Journal of Gastroenterology, 109(S1), S2–S26.
• Malfertheiner, P., Megraud, F., Rokkas, T., et al. (2022). Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report. Gut, 71(9), 1724–1762.
• Khanna, R., MacDonald, J.K., & Levesque, B.G. (2014). Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. Journal of Clinical Gastroenterology, 48(6), 505–512.
• Mayer, E.A. (2011). Gut feelings: the emerging biology of gut-brain communication. Nature Reviews Neuroscience, 12(8), 453–466.
• Camilleri, M. (2021). Diagnosis and treatment of irritable bowel syndrome: a review. JAMA, 325(9), 865–877.